Furyl and thienyl substituted taxanes and pharmaceutical...

Details Furyl and thienyl substituted taxanes and pharmaceutical... Furyl and thienyl substituted taxanes and pharmaceutical...

C - Chemistry, Metallurgy

07

D

C07D 407/12 (2006.01) A61K 31/34 (2006.01) A61K 31/38 (2006.01) A61K 31/395 (2006.01) A61K 31/695 (2006.01) C07D 305/14 (2006.01) C07D 407/14 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07F 7/00 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2077621

A taxane derivative of the formula Image wherein Image Z is -OT1, T1 is hydrogen, hydroxyl protecting group, or -COT2, T2 is H, C1-C6 alkyl, C1-C6 alkenyl, C1-C6 alkynyl or monocylic aryl, R3 is benzoyl, substituted benzoyl or C1-C6 alkoxycarbonyl, Ac is acetyl, and E1 and E2 are independently selected from hydrogen and functional groups which increase the water solubility of the taxane derivative are useful as antitumor agents.

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