Furyl or thienyl carbonyl substituted taxanes and...

Details Furyl or thienyl carbonyl substituted taxanes and... Furyl or thienyl carbonyl substituted taxanes and...

C - Chemistry, Metallurgy

07

D

C07D 407/12 (2006.01) A61K 31/335 (2006.01) A61K 31/34 (2006.01) A61K 31/38 (2006.01) A61K 31/395 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2147859

Taxane derivatives of formula (3) wherein R1 is phenyl or p-nitrophenyl, R3 is furyl or thienyl, T1 is hydrogen, hydroxyl protecting group, or -COT2, T2 is H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl or monocyclic aryl, Ac is acetyl, and E1 and E2 are independently selected from hydrogen and functional groups which increase the water solubility of the taxane deriva- tive are useful as antitumor agents.

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