Fused azepine derivatives and their use as antidiuretic agents

Details Fused azepine derivatives and their use as antidiuretic agents Fused azepine derivatives and their use as antidiuretic agents

C - Chemistry, Metallurgy

07

D

C07D 223/16 (2006.01) A61K 31/55 (2006.01) A61P 13/00 (2006.01) C07D 243/12 (2006.01) C07D 267/14 (2006.01) C07D 281/10 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 495/04 (2006.01) C07D 498/04 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2412555

Compounds according to general formulae (1 and 2), wherein G1 is an azepine derivative and G2 is a group according to general formulae (9 - 11) are new. Compounds according to the invention are vasopressin V2 receptor agonists. Pharmaceutical compositions of the compounds are useful as antidiuretic agents.

Cette invention concerne de nouveaux composés représentés par les formules générales (1 et 2) dans lesquelles G?1¿ est un dérivé d'azépine et G?2¿ un groupe représenté par les formules générales (9 - 11). Les composés selon l'invention sont des agonistes du récepteur V¿2? de la vasopressine. Les compositions pharmaceutiques tirées de ces composés sont utiles comme agents diurétiques.

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