C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 235/66 (2006.01) C07D 207/32 (2006.01) C07D 213/30 (2006.01) C07D 213/68 (2006.01) C07D 213/69 (2006.01) C07D 215/14 (2006.01) C07D 231/12 (2006.01) C07D 249/06 (2006.01) C07D 249/08 (2006.01) C07D 249/18 (2006.01) C07D 261/08 (2006.01) C07D 263/32 (2006.01) C07D 271/12 (2006.01) C07D 277/64 (2006.01) C07D 319/20 (2006.01)
Patent
CA 2592430
The invention relates to compounds of the formula (I) in which R1, R2, X, A, B, D and Y1 to Y4 have the meanings indicated in the claims, and/or a pharmaceutically acceptable salt and/or a prodrug thereof. Because of their properties as inhibitors of chemokine receptors, especially as CXCR2 inhibitors, the compounds of the formula I and the pharmaceutically acceptable salts and prodrugs thereof are suitable for the prevention and treatment of chemokine mediated diseases such as inflammatory diseases.
L'invention concerne des composés de formule (I) dans lesquels R1, R2, X, A, B, D et Y1 à Y4 ont les sens indiqués dans les revendications, et/ou un sel acceptable d'un point de vue pharmaceutique et/ou un promédicament de ceux-ci. En raison de leurs propriétés en tant qu'inhibiteurs des récepteurs de la chimiokine, particulièrement en tant qu'inhibiteurs de CXCR2, les composés de formule(I) et les sels acceptables d'un point de vue pharmaceutique et les promédicaments de ceux-ci conviennent pour la prévention et le traitement de maladies induites par la chimiokine telles que des maladies inflammatoires.
Czechtizky Werngard
Dedio Juergen
Grueneberg Sven
Heitsch Holger
Knieps Stephanie
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Sanofi-Aventis Deutschland Gmbh
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