Fused bicyclic derivatives of 2,4-diaminopyrimidine as alk...

Details Fused bicyclic derivatives of 2,4-diaminopyrimidine as alk... Fused bicyclic derivatives of 2,4-diaminopyrimidine as alk...

C - Chemistry, Metallurgy

07

D

C07D 239/48 (2006.01) A61K 31/495 (2006.01) A61P 35/00 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2669111

The present invention provides a compound of formula I or II or a pharmaceutically acceptable salt form thereof, wherein R1, R2, R3, R4, R5, A1, A2, A3, A4, and A5, are as defined herein. The compounds of formula I or II have ALK and/or c-Met inhibitory activity, and may be used to treat proliferative disorders.

L'invention concerne un compose de la formule I ou II, ou un sel pharmaceutiquement acceptable de celui-ci, où R1, R2, R3, R4, R5, A1, A2, A3, A4 et A5 sont tels que définis présentement. Les composés de la formule I ou II ont une activité inhibitrice de ALH et/ou C-MET et peuvent être utilisés pour traiter des troubles prolifératifs.

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