C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/14 (2006.01) A61K 31/4155 (2006.01) A61K 31/4245 (2006.01) A61K 31/4439 (2006.01) C07D 405/12 (2006.01) C07D 413/14 (2006.01)
Patent
CA 2648852
The present invention relates to a compound of formula (I): (I); or a pharmaceutically acceptable salt or solvate thereof, wherein: Ring A is (4-12)-membered heterocyclyl; Ring B is a fused benzene ring selected from the group consisting of: B(i); and B(ii); Ring A, ring B, ring C, R1, R1a, R2, R3, R4, L2, n, t, w, and z are as defined in the specification. The invention also relates to pharmaceutical compositions comprising the compounds of formula (I) and methods of treating a condition that is mediated by the modulation of glucokinase, the method comprising administering to a mammal an effective amount of a compound of formula (I).
La présente invention concerne un composé de formule (I): (I); ou des sels ou des solvates de ces composés acceptables sur le plan pharmaceutique, dans laquelle: le cycle A est un hétérocyclyle à membres (4-12); le cycle B est un cycle benzène fusionné choisi du groupe composé de: B(i); et B(ii); cycle A, cycle B, cycle C, R1, R1a, R2, R3, R4, L2, n, t, w, et z tels que définis dans la description. L'invention concerne aussi des compositions pharmaceutiques comprenant les composés de formule (I) et des méthodes de traitement d'une affection à médiation par glucokinase, cette méthode comprenant l'administration d'une dose efficace du composé de la formule (I) à un mammifère.
Bai Hao
Bailey Simon
Bhumralkar Dilip Ramakant
Bi Feng
Guo Fengli
Pfizer Products Inc.
Smart & Biggar
LandOfFree
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