Fused pyrrole compounds

Details Fused pyrrole compounds Fused pyrrole compounds

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/429 (2006.01) A61K 31/5025 (2006.01) C07D 498/04 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2517034

This invention relates to fused pyrrole compounds of Formula (I), and pharmaceutically acceptable salts and prodrugs thereof, wherein V1, V2, V3, V4, R1, R2, R3, W1 and W2 are as defined herein. The compounds of this invention may be used to prevent or treat cancer, inflammatory disorders, autoimmune diseases and other conditions involving PDE4 or elevated levels of cytokines. The invention also provides methods of using the compounds to treat or prevent such disorders and pharmaceutical compositions containing the compounds.

La présente invention se rapporte à des composés pyrroles condensés représentés par la formule (I), et à des sels pharmaceutiquement acceptables et des promédicaments de ces derniers. Dans ladite formule, V¿1?, V¿2?, V¿3?, V¿4?, R¿1?, R¿2?, R¿3?, W¿1? et W¿2? sont tels que définis dans le descriptif de l'invention. Les composés selon l'invention peuvent servir à prévenir ou traiter le cancer, des troubles inflammatoires, des maladies auto-immunes et d'autres états pathologiques mettant en jeu PDE4 ou des niveaux élevés de cytokines. L'invention concerne également des procédés d'utilisation des composés destinés à traiter ou à prévenir de tels troubles, et des compositions pharmaceutiques contenant lesdits composés.

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