C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/47 (2006.01)
Patent
CA 2674458
Fusion proteins comprising an antigen derived from NY-ESO-1 linked to an antigen derived from LAGE-1, which may further comprise carriers, fusion partners, or the like, are provided. Methods for preparing, formulating, and using such fusion proteins are also provided. Such proteins are useful a vaccine components for inducing an immune response against a range of cancer-antigen-bearing cells.
L'invention concerne des protéines hybrides comprenant un antigène dérivé de NY-ESO-1 lié à un antigène dérivé de LAGE-1, qui peuvent également comporter des vecteurs, des partenaires de fusion ou analogues. L'invention concerne également des méthodes de préparation, de formulation et d'utilisation desdites protéines hybrides. Ces protéines peuvent être utilisées comme constituants de vaccins pour induire une réponse immunitaire contre une gamme de cellules porteuses d'antigène de cancer.
Blais Normand
Boyer Martine
Brichard Vincent
Louahed Jamila
Martin Denis
Glaxosmithkline Biologicals S.a.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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