Fusions of a viral protein and a destructive enzyme

Details Fusions of a viral protein and a destructive enzyme Fusions of a viral protein and a destructive enzyme

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A01K 67/027 (2006.01) A61K 31/70 (2006.01) C07K 14/15 (2006.01) C07K 14/16 (2006.01) C12N 5/10 (2006.01) C12N 7/01 (2006.01) C12N 7/04 (2006.01) C12N 9/00 (2006.01) C12N 9/22 (2006.01) C12N 15/33 (2006.01) C12N 15/52 (2006.01) C12N 15/82 (2006.01) C12N 15/85 (2006.01) C12N 15/87 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2099268

A new type of dominant negative gene-fusion acts as an antiviral agent when expressed in infected cells. The dominant ne- gative effect is obtained by fusing a gene coding for a capsid or envelope protein of a virus to a gene coding for an enzyme (e.g.. nuclease or protease) that can destructively hydrolyze or modify the encapsulated viral DNA, RNA or proteins. The Fusion gene is expressed in virally infected cells; viruses assembled in these calls will then "self-destruct" because the fusion enzyme incorpo- rated in the viral particles destroys or functionally alters essential components of the virus, thus preventing the virus from produc- tively infecting another cell.

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