C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 21/00 (2006.01) A61K 39/02 (2006.01) C07K 14/195 (2006.01) C12N 1/20 (2006.01) C12N 9/20 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2138778
A method is provided for the enhanced elaboration of leukotoxin from F. necrophorum, and subsequent production of an inactivated leukotoxoid ruminant animal vaccine against F. necrophorum infection and consequent liver abscesses and/or foot rot in such animals. The method involves forming a culture of F. necrophorum bacteria in growth media, allowing the bacteria to grow therein and to simultaneously elaborate leukotoxin in a supernate; the culturing is preferably carried out at a temperature of from about 35-41 °C, a pH of from about 6.5-8, and for a period of from about 4-9 hours. At the end of the culturing, bacterial growth and leukotoxin elaboration are terminated, preferably by separating the leukotoxin supernate, whereupon the vaccine is produced by inactivation of at least the supernate.
Chengappa Muckatira M.
Nagaraja Tiruvoor G.
Gowling Lafleur Henderson Llp
Kansas State University Research Foundation
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