Fusogenic liposome composition and method

Details Fusogenic liposome composition and method Fusogenic liposome composition and method

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 9/127 (2006.01) A61K 31/4415 (2006.01) A61K 31/519 (2006.01)

Patent

CA 2505445

A fusogenic liposome composition for delivering a liposome-entrapped compound into the cytoplasm of a target cell is described. The liposomes have an outer surface coating of chemically releasable hydrophilic polymer chains which shield hydrophobic polymers on the liposomes outer surface. Release of the hydrophilic polymer chains exposes the hydrophobic polymers for interaction with outer cell membranes of the target cells to promote fusion of the liposome with the target cells. Also disclosed in a method for using the composition to deliver a compound to target cells, and a method far selecting suitable hydrophobic polymers for use in the composition.

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