G-protein coupled receptor (hofnh30)

Details G-protein coupled receptor (hofnh30) G-protein coupled receptor (hofnh30)

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/705 (2006.01) C07K 14/72 (2006.01) C07K 16/28 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2230971

HOFNH30 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also are methods for utilizing HOFNH30 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; diabetes, obesity; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension, urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles de la Tourett's syndrome, among others and diagnostic assays for such conditions.

Polypeptides et polynucléotides H0FNH30, et méthode pour produire ces polypeptides au moyen de techniques d'ADN recombinant. Sont également décrites des méthodes permettant d'utiliser les polypeptides et polynucléotides H0FNH30 dans la conception de protocoles de traitement de diverses affections, dont les infections causées par des bactéries, des champignons, des protozoaires et des virus, notamment les infections causées par le VIH-1 ou le VIH-2; la douleur; les cancers; le diabète; l'obésité; l'anorexie; la boulimie; l'asthme; la maladie de Parkinson; l'insuffisance cardiaque aiguë; l'hypotension; l'hypertension; la rétention urinaire; l'ostéoporose; l'angine de poitrine; l'infarctus du myocarde; les ulcères; l'asthme; les allergies; l'hypertrophie prostatique bénigne; et les troubles psychotiques et neurologiques comme l'anxiété, la schizophrénie, le trouble bipolaire, le délire, la démence, le retard mental sévère, et les dyskinésies comme la maladie de Huntington ou le syndrome de Gilles de la Tourette, de même que les épreuves diagnostiques permettant de détecter ces affections.

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