G protein coupled receptor protein, production and use thereof

C - Chemistry – Metallurgy – 12 – N

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C12N 15/12 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2162799

Rabbit gastropyrolic part smooth muscle-derived G protein coupled receptor proteins, partial peptides thereof; and DNAs containing said protein or partial peptide-encoding DNA are provided. The receptor protein and the DNA coding for said protein can be used for 1 determination of ligands; 2 acquisition of antibody and antiserum; 3 construction of expression system for of a recombinant type receptor protein; 4 development of the receptor binding assay system using said expression system and screening of the candidate compounds for pharmaceuticals; 5 conducting a drug design based upon a comparison with structurally analogous ligands and receptors; 6 preparation of probes and PCR primers for a gene diagnosis; 7 preparation of transgenic animals; and 8 preparation of model patient animals deficient in the receptor protein DNA. Elucidation of the structure and property of the G protein coupled receptor is particularly related to the development of unique pharmaceuticals which act on such a system.

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