G-rich polynucleotides for the treatment of huntington's...

Details G-rich polynucleotides for the treatment of huntington's... G-rich polynucleotides for the treatment of huntington's...

C - Chemistry, Metallurgy

07

H

C07H 21/04 (2006.01)

Patent

CA 2625035

The present invention relates to oligonucleotide compositions and therapeutic uses thereof to modify protein-protein interactions. In particular, the invention relates to the use of a guanidine-rich oligonucleotides to disrupt disease-causing protein aggregates, for example, Huntington's Disease (HD) protein aggregates.

La présente invention porte sur des compositions oligonucléotidiques et sur leurs utilisations thérapeutiques en vue de modifier les interactions protéine-protéine. L'invention porte, en particulier, sur l'utilisation d'un oligonucléotide riche en guanidine en vue de détruire des agrégats de protéine provoquant une maladie, par exemple, des agrégats de protéine provoquant la maladie de Huntington.

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