Galanin antagonist

Details Galanin antagonist Galanin antagonist

C - Chemistry, Metallurgy

07

K

C07K 14/435 (2006.01) A61K 38/04 (2006.01) A61K 38/17 (2006.01) C07K 7/02 (2006.01) C07K 7/08 (2006.01) C07K 7/18 (2006.01) C07K 7/22 (2006.01) C07K 14/575 (2006.01) C07K 14/70 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2109503

2109503 9220709 PCTABS00017 A galanin antagonist which is a galanin receptor ligand is described. Further, new peptides Galanin(1-12)-Pro-Substance P(5-11), Galanin(1-12)-Pro-Bradykinin(2-9), Galanin(1-12)-Pro-Pro-Pro-(Leu5-Enkephalin(5-1)), Galanin(1-12)-Pro-Lys(.epsilon.-NH-)Pro-(Leu5-Enkephalin(5-1)) and functional analogues and functional derivates thereof which exhibit substantially the same galanin antagonistic effect as said peptides are disclosed. Use of the galanin antagonist, a pharmaceutical preparation comprising it and a method of treating a disorder in a mammal which depends on the physiological function of galanin at the galanin receptor are also included.

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