Gamma secretase modulators

Details Gamma secretase modulators Gamma secretase modulators

C - Chemistry, Metallurgy

07

D

C07D 403/10 (2006.01) A61K 31/53 (2006.01) A61P 25/28 (2006.01) C07D 405/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 491/20 (2006.01) C07D 498/04 (2006.01) C07D 498/20 (2006.01) C07D 513/04 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2742602

In its many embodiments, the present invention provides a novel class of heterocyclic compounds of the formula: as modulators of gamma secretase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the central nervous system using such compounds or pharmaceutical compositions.

Dans ses nombreux modes de réalisation, la présente invention concerne une nouvelle classe de composés hétérocycliques de formule I en tant que modulateurs de sécrétase gamma, des procédés de préparation de tels composés, des compositions pharmaceutiques contenant un ou plusieurs de tels composés, des procédés de préparation de formulations pharmaceutiques comprenant un ou plusieurs de tels composés, et des procédés de traitement, prévention, inhibition, ou amélioration d'une ou plusieurs maladies associées au système nerveux central au moyen de tels composés ou compositions pharmaceutiques.

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