Gamma secretase modulators

Details Gamma secretase modulators Gamma secretase modulators

C - Chemistry, Metallurgy

07

D

C07D 403/10 (2006.01) A61K 31/4166 (2006.01) A61K 31/517 (2006.01) A61K 31/519 (2006.01) A61K 31/5365 (2006.01) A61P 25/28 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 498/04 (2006.01)

Patent

CA 2689948

In its many embodiments, the present invention provides a novel class of heterocyclic compounds of the formula: as modulators of gamma secretase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the central nervous system using such compounds or pharmaceutical compositions.

Dans ses nombreux modes de réalisation, cette invention concerne une nouvelle classe de composés hétérocycliques de formule (I), tels que des modulateurs de sécrétase gamma, des procédés de préparation de ces composés, des compositions pharmaceutiques contenant un ou plusieurs de ces composés, et des procédés de traitement, de prévention, d'inhibition ou d'amélioration d'une ou plusieurs maladies associées au système nerveux central au moyen de ces composés ou de ces compositions pharmaceutiques.

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