Ganglioside-klh conjugate vaccines with qs-21

Details Ganglioside-klh conjugate vaccines with qs-21 Ganglioside-klh conjugate vaccines with qs-21

A - Human Necessities

61

K

A61K 39/39 (2006.01) A61K 36/185 (2006.01) A61K 39/00 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) A61P 37/04 (2006.01)

Patent

CA 2154488

This invention provides a vaccine for stimulating or enhancing the production of an antibody which recognizes a ganglioside in a subject to which the vaccine is administered. The vaccine is comprised of an amount of ganglioside or oligosaccharide portion thereof conjugated to an immunogenic protein effective to stimulate or enhance antibody production in the subject. The vaccine is further comprised of an adjuvant and a pharmaceutically acceptable vehicle. The invention also provides a method of using the vaccine for treating or preventing cancer wherein gangliosides are on the surface or in the stroma of the cancer cells.

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