Gene deleted in colorectal cancer in humans

Details Gene deleted in colorectal cancer in humans Gene deleted in colorectal cancer in humans

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 14/82 (2006.01) C12N 15/10 (2006.01) C12N 15/12 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2073186

A new human gene termed DCC is disclosed. Methods and kits are provided for assessing mutations of the DCC gene in human tissues and body samples. Insertion, deletion, and point mutations in DCC are observed in human tumor cells. Normal tissues express DCC while most colorectal cancers do not. Loss of wild-type DCC genes is associated with neoplastic progression and a diminished life expectancy.

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