C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/86 (2006.01) A61K 48/00 (2006.01) A61P 19/00 (2006.01) C12N 5/10 (2006.01) C12N 15/861 (2006.01)
Patent
CA 2418977
The present invention relates to a gene delivery vehicle comprising a recombinant adenovirus having a tropism for a primary human chondrocyte. By efficiently transducing a nucleic acid of interest into a primary chondrocyte, said gene delivery vehicle is able to at least in part improve the counteraction of cartilage disease. In one embodiment said recombinant adenovirus comprises a deletion in the gene encoding for fiber protein, which is replaced by a nucleic acid sequence encoding at least part of a fiber protein of a B-type adenovirus.
La présente invention concerne un véhicule d'apport de gène comprenant un adénovirus recombiné présentant un tropisme vis-à-vis d'un chondrocyte humain primaire. Par une transduction efficace d'un acide nucléique d'intérêt en un chondrocyte primaire, ledit véhicule d'apport de gène est capable d'améliorer au moins en partie l'action contre une maladie du cartilage. Dans un mode de réalisation, ledit adénovirus recombiné comprend une délétion dans le gène codant la protéine fibreuse, lequel est remplacé par une séquence nucléotidique codant au moins une partie d'une protéine fibreuse d'un adénovirus de type B.
Bout Abraham
Havenga Menzo Jans Emco
Vogels Ronald
Borden Ladner Gervais Llp
Crucell Holland B.v.
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