C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C07H 21/04 (2006.01) C12P 19/34 (2006.01)
Patent
CA 2450126
A method of measuring the relative metabolic state of a multicellular organism is disclosed. In one embodiment, the method comprises the steps of: (a) obtaining a sample of nucleic acid isolataed from the organism's organ, tissue or cell, wehrein the nucleic acid is RNA or a cDNA copy of RNA, (b) determining the gene expression pattern of at least one of the genes selected from the group consisting of D31966, R74626, U79163, M22531, U43285, U79523, X81059, X84239, D38117, M70642, U37775, U84411, D87117, U31966, U51167, M97900, U32684, U43836, U60001, X61450, D49473, L08651, U28917, U49507, X59846, X00958, K03235, Z48238, M60596, AA117417, AF007267, AF011644, AJ001101, C79471, D16333, D49744, D83146, D86424, L29123, L40632, M74555, M91380, M93428, U19799, U20344, U34973, U35312, U35646, U43512, U47008, U47543, U56773, X06407, X54352, X84037, Y00746, Y07688, Z19581, Z46966, AF003695, AF020772, C76063, C79663, D10715, D12713, D67076, D86344, L10244, L18888, M57966, M58564, U19463, U25844, U27830, U35623, U43892, U51204, U75321, U84207, X52914, X54424, X75926, X99921 and Z74088 and (c) determining whether the gene expression profile of step (b) is more similar to a CR- induced metabolic state or a standard diet metabolic state.
L'invention concerne une méthode permettant de mesurer l'état métabolique relatif d'un organisme multicellulaire. Dans un mode de réalisation de l'invention, cette méthode comprend les étapes consistant à : (a) obtenir un échantillon d'un acide nucléique isolé à partir d'un organe, d'un tissu ou d'une cellule dudit organisme, l'acide nucléique étant de l'ARN ou une copie ADN complémentaire de l'ARN ; (b) déterminer le modèle d'expression génique d'au moins un des gènes sélectionnés dans le groupe comprenant D31966, R74626, U79163, M22531, U43285, U79523, X81059, X84239, D38117, M70642, U37775, U84411, D87117, U31966, U51167, M97900, U32684, U43836, U60001, X61450, D49473, L08651, U28917, U49507, X59846, X00958, K03235, Z48238, M60596, AA117417, AF007267, AF011644, AJ001101, C79471, D16333, D49744, D83146, D86424, L29123, L40632, M74555, M91380, M93428, U19799, U20344, U34973, U35312, U35646, U43512, U47008, U47543, U56773, X06407, X54352, X84037, Y00746, Y07688, Z19581, Z46966, AF003695, AF020772, C76063, C79663, D10715, D12713, D67076, D86344, L10244, L18888, M57966, M58564, U19463, U25844, U27830, U35623, U43892, U51204, U75321, U84207, X52914, X54424, X75926, X99921 et Z74088 ; et (c) déterminer si le profil d'expression génique de l'étape (b) ressemble plus à un état métabolique induit par restriction calorique (CR) ou à un état métabolique correspondant à un régime standard.
Kayo Tsuyoshi
Lee Cheol-Koo
Prolla Tomas A.
Weindruch Richard H.
Mccarthy Tetrault Llp
Wisconsin Alumni Research Foundation
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