Gene therapy vectors having reduced immunogenicity based on...

Details Gene therapy vectors having reduced immunogenicity based on... Gene therapy vectors having reduced immunogenicity based on...

C - Chemistry, Metallurgy

12

N

C12N 15/861 (2006.01) A61K 48/00 (2006.01) C07K 14/705 (2006.01) C12N 15/67 (2006.01)

Patent

CA 2522786

The present invention provides compositions and methods for specifically inhibiting host immune responses against expression vectors and target cells transfected with such vectors. In particular, methods of specifically inhibiting the humoral and cellular components of the host immune response to vector-associated antigens and target-cell associated antigens based on the use of CD8 alpha-chain are described.

La présente invention se rapporte à des compositions et à des procédés permettant d'inhiber de manière spécifique la réponse immunitaire d'un hôte contre des vecteurs d'expression et des cellules cibles transfectées avec de tels vecteurs. En particulier, l'invention concerne des procédés permettant d'inhiber de manière spécifique les composants humoraux et cellulaires de la réponse immunitaire d'un hôte contre des antigènes associés à des vecteurs et des antigènes associés à des cellules cibles.

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