Genes for the synthesis of antipathogenic substances

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/54 (2006.01) A01H 5/00 (2006.01) A01N 63/00 (2006.01) C07K 14/21 (2006.01) C12N 9/00 (2006.01) C12N 9/02 (2006.01) C12N 9/10 (2006.01) C12N 15/52 (2006.01) C12N 15/53 (2006.01) C12N 15/78 (2006.01) C12N 15/82 (2006.01) C12P 17/08 (2006.01) C12P 17/10 (2006.01) C12P 19/02 (2006.01) C12P 19/62 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2192366

The present invention is directed to the production of an antipathogenic substance (APS) in a host via recombinant expression of the polypeptides needed to biologically synthesize the APS. Genes encoding polypeptides necessary to produce particular antipathogenic substances are provided, along with methods for identifying and isolating genes needed to recombinantly biosynthesize any desired APS. The cloned genes may be transformed and expressed in a desired host organisms to produce the APS according to the invention for a variety of purposes, including protecting the host from a pathogen, developing the host as a biocontrol agent, and producing large uniform amounts of the APS.

La présente invention concerne la production d'une substance antipathogène (SAP) chez un hôte par la production de polypeptides de recombinaison nécessaires pour la synthèse biologique de la SAP. Elle concerne également des gènes codant pour les polypeptides nécessaires à la production de SAP particulières, ainsi que des méthodes pour identifier et isoler les gènes nécessaires à la biosynthèse de SAP de recombinaison souhaitées. Les gènes clonés peuvent être transformés et exprimés dans divers organismes hôtes pour produire les SAP selon l'invention utiles à divers titres, par exemple pour protéger l'hôte contre un agent pathogène, pour se servir de l'hôte comme d'un agent de contrôle biologique et pour produire de grandes quantités de SAP de qualité régulière.

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