Genetic analysis for stratification of cancer risk

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01) C07H 21/04 (2006.01)

Patent

CA 2460721

The present invention provides new methods for the assessment of cancer risk in the general population. These methods utilize particular alleles of two or more genes, in combination, to identify individuals with increased or decreased risk of cancer. Exemplified is risk assessment for breast cancer in women. In addition, personal history measures such as age and race are used to further refine the analysis. Using such methods, it is possible to reallocate healthcare costs in cancer screening to patient subpopulations at increased cancer risk. It also permits identification of candidates for cancer prophylactic treatment.

L'invention concerne de nouvelles méthodes pour l'évaluation du risque de cancer dans la population générale. Selon lesdites méthodes, on utilise des allèles particuliers de deux ou plusieurs gènes, en combinaison, afin d'identifier les individus présentant un risque élevé ou faible de développer un cancer. On prend comme exemple l'évaluation du risque de cancer du sein chez les femmes. De plus, on utilise des renseignements personnels tels que l'âge et la race pour affiner encore l'analyse. Grâce à de telles méthodes, il est possible de redistribuer les coûts médicaux pour le dépistage du cancer chez les sous-populations de patients présentant un risque élevé de développer un cancer. Cela permet également l'identification des candidats au traitement prophylactique du cancer.

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