Genetic inhibition by double-stranded rna

Details Genetic inhibition by double-stranded rna Genetic inhibition by double-stranded rna

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) C12N 15/63 (2006.01) C12N 15/82 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2311999

A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.

L'invention porte sur un procédé pouvant s'opérer ex vivo ou in vivo consistant à introduire de l'ARN dans une cellule vivante pour inhiber l'expression génique d'un gène cible de cette cellule. L'ARN possède une région à structure double brin. L'inhibition est spécifique d'une séquence en ce sens que les séquences nucléotidiques de la région double de l'ARN et d'une partie du gène cible sont identiques. Ladite invention diffère des interférences avec l'expression génique des techniques antérieures par l'utilisation de procédés antisens ou à triple brin.

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