Genetic variations associated with drug resistance

Details Genetic variations associated with drug resistance Genetic variations associated with drug resistance

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2715319

Methods and compositions are provided to determine if a cancer is resistant to treatment with anti-mitotic agents, including treatment with T-DM 1. The methods relate to determining if the ABCC3 gene is amplified and/or overexpressed in the cancer.

La présente invention concerne des procédés et des compositions pour déterminer si un cancer est résistant à un traitement par des agents antimitotiques, et notamment à un traitement par du T-DM1. Les procédés consistent à déterminer si le gène ABCC3 est amplifié et/ou surexprimé dans le cancer.

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