Glial cell line-derived neurotrophic factor receptors

Details Glial cell line-derived neurotrophic factor receptors Glial cell line-derived neurotrophic factor receptors

A - Human Necessities

61

K

A61K 38/00 (2006.01) A01N 37/18 (2006.01) C07K 1/00 (2006.01) C07K 14/00 (2006.01) C07K 14/71 (2006.01) C07K 17/00 (2006.01)

Patent

CA 2290426

Receptors for Glial Cell Line-Derived Neurotrophic Factor (GDNF), their cellular expression, isolation, biochemical characterization, and sequences are disclosed. c-RET is disclosed as one receptor for GDNF; additional novel receptors are also disclosed. The preparation of monoclonal antibodies directed against GDNF is also disclosed.

Récepteurs du facteur neurotrophique dérivé de lignes de cellules gliales (GDNF), leur expression cellulaire, leur isolation, leur caractérisation biochimique et leurs séquences. L'invention concerne c-RET en tant qu'un récepteur de GDNF, ainsi que de nouveaux récepteurs supplémentaires. Elle concerne également la préparation d'anticorps monoclonaux dirigés contre GDNF.

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