C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/14 (2006.01) A61K 31/4545 (2006.01) A61P 3/10 (2006.01)
Patent
CA 2637172
Provided are compounds of formula I that are useful in the treatment and/or prevention of diseases mediated by deficient levels of glucokinase activity, such as diabetes mellitus. Also provided are methods of treating or preventing diseases and disorders characterized by underactivity of glucokinase or which can be treated by activating glucokinase. (Formula I) wherein R2, L, Z, Y, G and R1 are as defined in the claims.
L'invention concerne des composés représentés par la formule (I) servant au traitement et/ou à la prévention de maladies à médiation par des niveaux déficients de l'activité de glucokinases, tels que le diabète sucré. L'invention concerne également des procédés de traitement et/ou de prévention de maladies et de troubles caractérisés par l'hypoactivité de glucokinases ou pouvant être traités par l'activation de glucokinases. Les symboles R2, L, Z, Y, G et R1 de la formule (I) ont la signification donnée dans le descriptif.
Aicher Thomas Daniel
Boyd Steven Armen
Chicarelli Mark Joseph
Condroski Kevin Ronald
Hinklin Ronald J.
Array Biopharma Inc.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
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