Glutamate aggrecanase inhibitors

Details Glutamate aggrecanase inhibitors Glutamate aggrecanase inhibitors

C - Chemistry, Metallurgy

07

C

C07C 237/22 (2006.01) A61K 31/166 (2006.01) A61K 31/36 (2006.01) A61K 31/381 (2006.01) A61K 31/426 (2006.01) A61K 31/4409 (2006.01) C07C 231/16 (2006.01) C07C 235/84 (2006.01) C07C 237/42 (2006.01) C07C 259/06 (2006.01) C07C 323/41 (2006.01) C07D 213/56 (2006.01) C07D 277/30 (2006.01) C07D 317/58 (2006.01) C07D 333/24 (2006.01)

Patent

CA 2614930

The present invention relates to compounds of the formula (I), which are modulators of metalloproteinase activity. and pharmaceutically acceptable salts thereof, wherein W is -C(O)-, -OC(O)-, -NHC(O)-, -C(O)O-, Or -C(O)NH-; R1 is phenyl, heteroaryl, biphenyl, bicyciic aryi, tricyclic aryl, bicyclic heteroaryl. or tricyclic heteroaryl, each optionally substituted with one or more of R5 or R6, and when Ri is substituted with more than one of R5 or Re, the substituents can be identical or different; R2 is hydrogen, (C1 -C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkynyl, -(CH2)nR11 , -OH, or -0-(C1-C6) alkyl; R3 is -CO2H, -CONH2, -CONHOH, -CONHSO2R7, tetrazole, -SO2NHR7, -SO3H, - PO(OH)NH2, -PO(OH)OR7, -CONHR7, -COOR7, an acid mimetic group, or a 5 or 6- membered heterocycloalkyl or heteroaryl containing 1 to 4 heteroatoms selected from O, N, S; R4 is -CO2H, -CONH2, -(CH2)nOR7, or -CONR9R10;

Cette invention concerne des modulateurs d'activité de métalloprotéinase.

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