Gonadoliberin derivatives and process for the preparation...

Details Gonadoliberin derivatives and process for the preparation... Gonadoliberin derivatives and process for the preparation...

C - Chemistry, Metallurgy

07

K

530/7.06, 530/7.

C07K 7/06 (2006.01) C07K 7/23 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1268897

Abstract The invention relates to gonadoliberin derivatives of the general formula (I) Glp-His-Trp-Ser-Tyr-X1-X2-X3-Pro-X4 wherein X1 is a glycyl group or a D-isomer of any natural or synthetic amino acid group, X2 represents an L-amino acid group having 1 to 4 carbon atoms in the side chain, L-phenyl- -alanyl or L-tryptophyl group, X3 represents an L-amino acid group having a C1-4 alkyl or C2-4 alkanoyl-amide side chain, and X4 is a glycine amide or a C1-4 alkyl amide group, with the proviso that if X1 stands for a group other than glycyl and X2 is a tryptophyl group then X3 may not be leucyl, and the addition salts formed with therapeutically use- able acids and complexes thereof. Furthermore the inven- tion relates to a process for preparing these compounds. The new gonadoliberin derivatives can be effectively used for the reproduction process of fish, birds and mammals.

470789

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