Gpcr-proteins and nucleic acids encoding same

Details Gpcr-proteins and nucleic acids encoding same Gpcr-proteins and nucleic acids encoding same

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/16 (2006.01) A61K 48/00 (2006.01) A61P 5/48 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) C12Q 1/68 (2006.01) G01N 33/573 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2406370

Disclosed herein are nucleic acid sequences that encode G-coupled protein- receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

L'invention concerne des séquences d'acides nucléiques codant pour des polypeptides du récepteur couplé à la protéine G. L'invention concerne également des polypeptides codés par ces séquences d'acides nucléiques, et des anticorps capables de liaison immunospécifique avec le polypeptide, ainsi que des dérivés, des variants, des mutants ou des fragments des polypeptides, des polynucléotides ou des anticorps susmentionnés. En outre, l'invention concerne des méthodes thérapeutiques, diagnostiques et de recherche permettant de diagnostiquer, de traiter et de prévenir les troubles associés à l'un de ces protéines et acides nucléiques humains.

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