Graft rejection suppressors

Details Graft rejection suppressors Graft rejection suppressors

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 31/135 (2006.01) A61K 31/16 (2006.01) A61K 31/42 (2006.01) A61K 31/436 (2006.01) A61K 31/52 (2006.01) A61K 31/5377 (2006.01) A61K 31/573 (2006.01) A61K 31/7056 (2006.01) A61K 38/13 (2006.01) A61K 38/17 (2006.01) A61P 37/06 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2439858

It was found that antibodies against AILIM (also known as ICOS and 8F4) and AILIM-Ig have significant therapeutic effects towards the suppression and prevention of graft rejection. Graft rejection is a serious problem associated with tissue or organ transplantation (allotransplantation or xenotransplantation), performed to treat various organ failures (liver, heart, lung, kidney, pancreas, etc.).

On a découvert qu'un anticorps dirigé contre AILIM (également désigné ICOS et 8F4) et AILIM-Ig ont un effet thérapeutique suffisant pour inhiber ou empêcher le rejet du greffe, qui représente un grave problème lors de la transplantation de tissus ou d'organes (homogreffe et hétérogreffe), effectuée pour traiter les insuffisances de différents organes (foie, coeur, poumon, reins, pancréas, etc.).

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