Guanidino protease inhibitors

Details Guanidino protease inhibitors Guanidino protease inhibitors

C - Chemistry, Metallurgy

07

D

C07D 211/26 (2006.01) A61K 31/155 (2006.01) A61K 31/18 (2006.01) A61K 31/255 (2006.01) A61K 31/275 (2006.01) A61K 31/33 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) A61K 31/66 (2006.01) C07C 279/04 (2006.01) C07C 279/12 (2006.01) C07C 309/72 (2006.01) C07C 309/73 (2006.01) C07C 311/21 (2006.01) C07D 207/08 (2006.01) C07D 211/22 (2006.01) C07D 295/215 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/00 (2006.01) C07D 405/00 (2006.01) C07D 409/00 (2006.01) C07D 413/00 (2006.01) C07D 417

Patent

CA 2233344

Compounds of formula (I) wherein R1-R4, R7-R8, Ra, Rb, Rc, Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit a number of proteolytic enzymes are described. Also described are methods for preparing the compounds of Formula (I).

L'invention concerne des composés guanidino ayant la formule (I). Dans cette formule, R?1¿-R?4¿, R?7¿-R?8¿, R?a¿, R?b¿, R?c¿, Y, Z, n et m sont expliqués dans la description. L'invention concerne également des hydrates, des solvates de ces composés ou encore des sels de ceux-ci acceptables sur le plan pharmaceutique. Ces composés inhibent un certain nombre d'enzymes protéolytiques. L'invention concerne également des procédés de préparation des composés de la formule (I).

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