Guanidino-substituted quinazolinone compounds as mc4-r agonists

Details Guanidino-substituted quinazolinone compounds as mc4-r agonists Guanidino-substituted quinazolinone compounds as mc4-r agonists

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/517 (2006.01) A61K 31/5377 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) C07D 239/91 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2523015

A variety of small molecule, guanidine-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases when administered to subjects. The compounds have the structure IA, IB, and IC where the values of the variables are defined herein.

L'invention concerne une variété de petites molécules contenant de la guanidine, ces molécules pouvant agir comme agonistes du récepteur MC4-R. Les composés selon l'invention peuvent être administrés à des sujets en traitement de maladies à médiation par le récepteur MC4-R. Lesdits composés possèdent la structure IA, IB et IC, les valeurs des variables étant telles que définies dans la description.

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