C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/38 (2006.01) A61K 31/66 (2006.01) C07F 9/40 (2006.01) C07F 9/547 (2006.01) C07F 9/6506 (2006.01)
Patent
CA 2085171
Guanidinoalkyl-1,1-bisphosphonic acid derivatives, process for their preparation and their use The invention describes tautomeric compounds of the formula Ia, Ib or Ic (see Formula Ia, Ib) (see Formula Ic) and/or their physiologically tolerable salts, in which R1, R2, R3, R4, R5, R6 and R7 are a hydrogen atom, substituted (C1-C7)-alkyl, (C3-C10)-cycloalkyl, substituted phenyl or (C1-C4)-alkylphenyl, R2 is substituted phosphoric acid, R2 and R3, R2 and R5 or R4 and R5 form a monocyclic 5- to 7-membered saturated or unsaturated heterocyclic ring which is mono- or polysubstituted, R8, R9, R10 and R11 are a hydrogen atom or (C1-C5)-alkyl, X is a hydrogen atom, hydroxyl or halogen, 1 and n are an integer from 0 to 7, m is an integer from 0 to 2, and the sum of the numbers l, m and n is less than or equal to 10, a process for the preparation of the compounds of the formula Ia, Ib or Ic, pharmaceuticals and their use for the prophylaxis or treatment of osteoporosis.
Carniato Denis
Katoh Masakazu
Lang Hans-Jochen
Moura Anne-Marie
Naumann Christoph
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Hoechst Aktiengesellschaft
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