Haemophilus influenzae type iv pili

Details Haemophilus influenzae type iv pili Haemophilus influenzae type iv pili

C - Chemistry, Metallurgy

07

K

C07K 14/285 (2006.01) A61K 38/16 (2006.01) A61K 39/102 (2006.01) C07K 16/12 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2550455

The invention described herein relates to a Haemophilus influenzae (H. influenzae) regulon encoding type IV pili. In particular, the invention relates to type IV pili from nontypeable H. influenzae (NTHi) and from H. influenzae strains a, b, c, e and f. The invention provides isolated H. influenzae pilus polynucleotides and polypeptides encoded by the polynucleotides as well as polynucleotides and polypeptides encoded by the polynucleotides involved in the assembly/disassembly of the structure. The invention also relates to uses of these polynucleotides and/or polypeptides including methods for eliciting an immune response to H. influenzae and methods of treating and preventing H. influenzae related pathological conditions.

L'invention concerne un régulon de l'Haemophilus influenzae (H. influenzae) codant des pili de type IV. Elle concerne en particulier des pili de type IV issus de H. influenzae non typable (NTHi) et des souches a, b, c, e et f de H. influenzae. On décrit des polynucléotides isolés du pilus de H. influenzae et des polypeptides codés par les polynucléotides, ainsi que des polynucléotides et polypeptides codés par les polynucléotides impliqués dans l'assemblage/le désassemblage de la structure. L'invention concerne en outre des utilisations desdits polynucléotides et/ou polypeptides, notamment des méthodes destinées à éliciter une réponse immunitaire contre H. influenzae, et des méthodes de traitement et de prévention d'états pathologiques associés à H. influenzae.

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