Haemophilus transferrin receptor genes

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/285 (2006.01) A61K 39/102 (2006.01) A61K 39/395 (2006.01) C07K 7/04 (2006.01) C07K 7/06 (2006.01) C07K 16/12 (2006.01) C12N 15/31 (2006.01)

Patent

CA 2175332

Purified and isolated nucleic acid is provided which encodes a transferrin receptor protein of a strain of Haemophilus or a fragment or an analog of the transferrin receptor protein. The nucleic acid sequence may be used to produce peptides free of contaminants derived from bacteria normally containing the Tbp1 or Tbp2 proteins for purposes of diagnostics and medical treatment. Furthermore, the nucleic acid molecule may be used in the diagnosis of infection. Also provided are recombinant Tbp1 or Tbp2 and methods for purification of the same. Live vectors expressing epitopes of transferrin receptor protein for vaccination are provided.

L'invention concerne un acide nucléique purifié et isolé qui code une protéine réceptrice de la transferrine d'une souche dHaemophilus ou d'un fragment ou d'un analogue de la protéine réceptrice de la transferrine. La séquence d'acide nucléique peut permettre de produire des peptides dépourvus de contaminants, dérivés de bactéries contenant normalement les protéines Tbp1 ou Tbp2 pour des utilisations en thérapeutique ou pour effectuer des diagnostics. En oute, la molécule d'acide nucléique peut être utilisée dans le diagnostic de l'infection. L'invention concerne également des Tbp1 ou Tbp2 de recombinaison et des procédés de purification de ces dernières, ainsi que des vecteurs vivants exprimant les épitopes de la protéine réceptrice de la transferrine dans un but de vaccination.

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