Halo substituted aminotetralins

Details Halo substituted aminotetralins Halo substituted aminotetralins

C - Chemistry, Metallurgy

07

C

260/329.3, 260/5

C07C 217/74 (2006.01) C07C 211/42 (2006.01) C07C 211/60 (2006.01) C07C 323/38 (2006.01)

Patent

CA 2026775

This invention is therapeutically useful tetralins and pharmaceutically acceptable acid addition salts thereof of the formula (see fig.I) wherein X1 is -OR3; wherein R3 is alkyl(C1-C8); alkenyl(C1-C8), -CH2-cycloalkyl(C3-C8) or benzyl; wherein R4 is alkyl(C1-C3); wherein X2 is hydrogen, CF3 or halogen; wherein R7 is hydrogen or methyl; wherein R1 is hydrogen, alkyl(C1-C3), or cyclopropylmethyl; wherein R2 is -CH2-cycloalkyl(C3-C8), alkyl(C1-C8), -(CH2)q-R5 or -CH2CH2-Z-(CH2)rCH3; wherein R5 is phenyl, 2-thiophene or 3-thiophene; wherein Z is oxygen or sulfur; and wherein p is one or 2, q is 2 or 3, and r is zero to 3; with the proviso that when p is 2, X1 is at the 5- or 8- position. These compounds are useful to treat central nervous system disorders.

Tétralines et leurs sels d'addition acceptables en pharmacie, agents thérapeutiques, de formule (voir fig. I), où X1 est -OR3; R3 est un alkyle (C1-C8), un alcényle (C1-C8), un -CH2-cycloalkyle (C3-C8) ou un benzyle; R4 est un alkyle (C1-C3); X2 est un hydrogène, CF3 ou un halogène; R7 est un hydrogène ou un méthyle; R1 est un hydrogène, un alkyle (C1-C3) ou un cyclopropylméthyle; R2 est un -CH2-cycloalkyle (C3-C8), un alkyle (C1-C8), -(CH2)q-R5 ou -CH2CH2-Z-(CH2)rCH3; R5 est un phényle, un 2-thiophène ou 3-thiophène; Z est un oxygène ou un soufre; p est 1 ou 2, q est 2 ou 3, et r est un entier de 0 à 3; à la condition que lorsque p est 2, X1 est en position 5- ou 8-. Ces composés sont utiles pour traiter les troubles du système nerveux central.

Affiliated with

Also associated with

Rating

Halo substituted aminotetralins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Halo substituted aminotetralins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Halo substituted aminotetralins will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1950410