Halo-substituted protein kinase c inhibitors

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 498/22 (2006.01) A61K 47/16 (2006.01) C07D 487/22 (2006.01) C07D 491/22 (2006.01) C07D 513/22 (2006.01)

Patent

CA 2252701

The present invention is directed to novel halo-substituted bis- indolemaleimide compounds of formula (I). The invention further provides a method of preparing the disclosed compounds and the preparation of pharmaceutical formulation for use in inhibiting Protein Kinase C in mammals.

La présente invention se rapporte à de nouveaux composés de bis-indolemaléimide halo-substitués de la formule (I), ainsi qu'à un procédé de préparation des composés décrits et à la préparation d'une formulation pharmaceutique destinée à inhiber la protéine kinase C chez les mammifères.

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