Haloacetal compound

C - Chemistry – Metallurgy – 07 – C

Patent

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Details

260/476.3, 260/5

C07C 323/62 (2006.01) C07D 337/14 (2006.01)

Patent

CA 1311492

HALOACETAL COMPOUND ABSTRACT A haloacetal compound obtained in a process for the preparation of 2-(10,11-dihydro-10-oxodibenzo[b,f]thiepin- 2-yl)propionic acid which shows high anti-inflammatory and analgetic action is disclosed. The process starts from a propiophenone derivative having the formula (II): (II) Image wherein R1 is hydrogen or a lower alkyl group, which is once converted into the haloacetal compound via a haloketone compound, and then converted into the desired dibenzothiepin derivative through a combination of rearrangement, hydrolysis and ring closure in variable sequence.

615947

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