C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
260/476.3, 260/5
C07C 323/62 (2006.01) C07D 337/14 (2006.01)
Patent
CA 1311492
HALOACETAL COMPOUND ABSTRACT A haloacetal compound obtained in a process for the preparation of 2-(10,11-dihydro-10-oxodibenzo[b,f]thiepin- 2-yl)propionic acid which shows high anti-inflammatory and analgetic action is disclosed. The process starts from a propiophenone derivative having the formula (II): (II) Image wherein R1 is hydrogen or a lower alkyl group, which is once converted into the haloacetal compound via a haloketone compound, and then converted into the desired dibenzothiepin derivative through a combination of rearrangement, hydrolysis and ring closure in variable sequence.
615947
Masaki Mitsuo
Moritoh Naoya
Takahashi Toshihiro
Takeda Hiromitsu
Bereskin & Parr
Nippon Chemiphar Co. Ltd.
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