Hbv precore protein having a particle-forming ability

Details Hbv precore protein having a particle-forming ability Hbv precore protein having a particle-forming ability

C - Chemistry, Metallurgy

07

K

C07K 14/02 (2006.01) A61K 39/29 (2006.01) A61P 1/16 (2006.01) A61P 31/12 (2006.01) C07K 14/08 (2006.01) C12N 7/00 (2006.01) C12N 7/04 (2006.01) G01N 33/576 (2006.01)

Patent

CA 2497972

It is intended to provide an HBV precore protein capable of forming particles and a means of assaying the same. A novel HBV precore protein forming HBV virus-like particles is identified. Thus, this novel HBV precore protein is provided. It is also intended to provide core-like particles and virus-like particles formed by this HBV precore protein. These virus-like particles are usable in vaccines and remedies. Moreover, it is intended to provide a method of assaying the HBV precore protein and a method of assaying an anti-HBV precore protein antibody.

L'objectif de cette invention est d'obtenir une protéine pré-noyau du virus de l'hépatite B (VHB) capable de former des particules ainsi qu'un moyen de bioanalyse de ladite protéine. Selon la présente invention, une nouvelle protéine pré-noyau du VHB formant des particules assimilées au virus de l'hépatite B est donc identifiée. L'objectif de cette invention est également d'obtenir des particules assimilées au noyau ainsi que des particules assimilées au virus formées par cette protéine pré-noyau du VHB, lesdites particules assimilées au virus pouvant être utilisées dans des vaccins et des remèdes. De plus, cette invention concerne une méthode de bioanalyse de ladite protéine pré-noyau du VHB ainsi qu'une méthode de bioanalyse d'un anticorps anti-protéine pré-noyau du VHB

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