C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/705 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61P 31/14 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) C12N 15/85 (2006.01) C12N 15/86 (2006.01)
Patent
CA 2649962
The invention relates to the discovery that the Claudin-1 protein functions as a co-receptor for entry of HCV into cells. Methods of inhibiting, preventing or mitigating HCV infections by inhibiting HCV interactions with Claudin-1 are provided. Methods of identifying agents or compounds that interfere with HCV interactions with Claudin-1 are also provided. Finally, useful kits, cell culture compositions, agents, and compounds related to the inhibition of HCV interactions with Claudin-1 are also disclosed.
L'invention porte sur la découverte que la protéine claudine 1 joue un rôle de co-récepteur pour l'entrée du VHC dans la cellule. Sont décrites des méthodes d'inhibition, de prévention ou d'atténuation d'infection par le virus de l'hépatite C, ces méthodes consistant à inhiber les interactions du VHC avec claudine 1. Sont également décrites des méthodes permettant d'identifier des agents ou des composés qui entravent les interactions du VHC avec claudine 1. L'invention concerne enfin des trousses, des compositions de cultures de cellules, des agents et des composés utiles en ce qui concerne l'inhibition des interactions du VHC avec claudine1.
Evans Matthew J.
Rice Charles
von Hahn Thomas
Mcfadden Fincham
The Rockefeller University
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