Heart-rate reducing benzazepinone derivatives

Details Heart-rate reducing benzazepinone derivatives Heart-rate reducing benzazepinone derivatives

C - Chemistry, Metallurgy

07

D

260/238

C07D 223/16 (2006.01) C07C 59/64 (2006.01) C07D 205/04 (2006.01) C07D 243/02 (2006.01) C07D 243/04 (2006.01) C07D 243/10 (2006.01) C07D 491/04 (2006.01) C07D 491/056 (2006.01)

Patent

CA 1185239

ABSTRACT OF THE DISCLOSURE Compounds of general formula I Image (I) wherein A represents a -CH2-CH2 , -CH=CH-, Image , or Image group, wherein R7 represents a lower alkyl group, and B represents a methylene or carbonyl group or A represents a -CO-CO- group and B represents a methylene group; E represents an optionally substitituted ethylene, n-propylene or n-butylene group; G represents an optionally substituted methylene or ethylene group; R1 and R2 represent a hydroxy, alkyl, alkoxy or phenyl- alkoxy group; R3 and R4 represent hydrogen atoms, halogen atoms, trifluoromethyl, hydroxy, alkyl, alkoxy or cyano groups; R5 represents a hydrogen atom, an alkyl, hydroxy, alkoxy or optionally substituted amino group; and R6 represents a hydrogen atom, an alkyl, alkenyl, phenylalkyl and or acyl group; and acid addition salts thereof. Processes for the preparation of the new compounds as well as pharmaceutical compositions containing them are also objects of this invention. The new compounds show valuable pharmacological properties, especially heart-rate reducing activity.

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