Helicobacter proteins, nucleic acids and uses thereof

Details Helicobacter proteins, nucleic acids and uses thereof Helicobacter proteins, nucleic acids and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) A61K 31/7088 (2006.01) A61K 39/02 (2006.01) A61K 39/40 (2006.01) A61K 48/00 (2006.01) C07K 14/195 (2006.01) C07K 14/205 (2006.01) C07K 16/12 (2006.01) C07K 19/00 (2006.01) C12N 15/63 (2006.01) C12Q 1/68 (2006.01) G01N 33/569 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2430930

The invention discloses Helicobacter HP30 or HP56 polypeptide, polypeptides derived thereof (HP30-derived or HP56-derivedpolypeptides), nucleic acids encoding said polypeptides, antibodies that specifically bind the HP30, HP56, HP30-derived or HP56-derived polypeptides and T cells specific for HP30, HP56, HP30-derived or HP56-derived polypeptide. Also disclosed are prophylactic or therapeutic compositions, including immunogenic compositions, e.g. vaccines, comprising HP30, HP56, HP30-derived or HP56-derived polypeptides, nucleic acids encoding the same or antibodies thereto. The invention additionally discloses methods of inducing in animals an immune response to Helicobacter cells or antigens.

La présente invention concerne un polypeptide HP30 ou HP56 deHelicobacter, des polypeptides dérivés de ces derniers (polypeptides dérivés de HP30 ou de HP56), des acides nucléiques codant ces polypeptides, des anticorps qui se fixent de façon spécifique sur les polypeptides HP30, HP56, dérivés de HP30 ou dérivés de HP56 et des lymphocytes T spécifiques aux polypeptides HP30, HP56, dérivés de HP30 ou dérivés de HP56. L'invention concerne aussi des compositions préventives ou thérapeutiques, y compris des compositions immunogènes, telles que des vaccins, comprenant les polypeptides HP30, HP56, dérivés de HP30 ou dérivés de HP56, des acides nucléiques codant ces derniers, ou des anticorps de ces derniers. L'invention concerne également des méthodes permettant d'induire une réponse immune aux cellules ou aux antigènes Helicobacter chez des animaux.

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