Hepatitis c inhibitor peptide analogs

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 401/12 (2006.01) A61K 31/4709 (2006.01) A61P 31/14 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2573346

The invention relates to compounds of formula (I) wherein R1, R2, R3, R4, R5, Y, n and m are as defined herein. The compounds are useful for the treatment and prevention of hepatitis C viral infection in mammals by inhibiting HCV NS3 protease. The invention further relates to azalactone compounds of the formula (III) which can be reacted with an amide anion to produce the compounds of formula (I).

L'invention concerne des composés représentés par la formule (I), dans laquelle R1, R2, R3, R4, R5, Y, n et m sont tels que définis dans le descriptif. Ces composés peuvent servir à traiter et à prévenir l'infection par le virus de l'hépatite C chez les mammifères, par l'inhibition de la protéase NS3 du VHC. L'invention concerne en outre des composés d'azalactone représentés par la formule (III), permettant de produire les composés représentés par la formule (I), par réaction avec un anion amide.

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