C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/861 (2006.01) A61K 39/39 (2006.01) A61K 48/00 (2006.01) C07K 14/18 (2006.01) C12N 15/51 (2006.01) C12N 15/85 (2006.01)
Patent
CA 2718802
The present invention features Ad6 vectors and a nucleic acid encoding a Met-NS3--NS4A-NS4B-NS5A-NS5B polypeptide containing an inactive NS5B RNA- dependent RNA polymerase region. The nucleic acid is particularly useful as a component of an adenovector or DNA plasmid vaccine providing a broad range of antigens for generating an HCV specific cell mediated immune (CMI) response against HCV.
Bett Andrew J.
Colloca Stefano
Cortese Riccardo
Emini Emilio A.
Kaslow David C.
Gowling Lafleur Henderson Llp
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.p.a.
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.r.l.
Merck Sharp & Dohme Corp.
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