C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 50/26 (2006.01) A61K 31/122 (2006.01) A61P 3/00 (2006.01) C07D 209/12 (2006.01) C07D 213/50 (2006.01) C07D 231/12 (2006.01) C07D 233/64 (2006.01) C07D 237/08 (2006.01) C07D 263/32 (2006.01) C07D 277/24 (2006.01) C07D 307/46 (2006.01) C07D 333/22 (2006.01)
Patent
CA 2708961
Methods of treating or suppressing mitochondrial diseases, such as Friedreich's ataxia (FRDA), Leber's Hereditary Optic Neuropathy (LHON), mitochondrial myopathy, encephalopathy, lactacidosis, stroke (MELAS), Kearns- Sayre Syndrome (KSS), are disclosed, as well as compounds useful in the methods of the invention, such as 2-(3-hydroxy-3-methyl--butyl)-6-(het)aryl-p-quinone or as 2-(3- hydroxy-3- methylbutyl)-3-(het)aryl-p-quinone derivatives. Energy biomarkers useful in assessing the metabolic state of a subject and the efficacy of treatment are also disclosed. Methods of modulating, normalizing, or enhancing energy biomarkers, as well as compounds useful for such methods, are also disclosed.
L'invention concerne des procédés de traitement ou de suppression de maladies mitochondriales, telles que l'ataxie de Friedreich (FRDA), la neuropathie optique héréditaire de Leber (LHON), la myopathie mitochondriale, l'encéphalopathie, la lactacidose, les accidents vasculaires cérébraux (MELAS), le syndrome de Kearns-Sayre (KSS), de même que des composés utiles dans les procédés de la présente invention, tels que de la 2-(3-hydroxy-3-méthylbutyl)-6-(hét)aryl-p-quinone ou des dérivés de 2-(3-hydroxy-3-méthylbutyl)-3-(hét)aryl-p-quinone. Des biomarqueurs énergétiques utiles pour évaluer l'état métabolique d'un sujet et l'efficacité d'un traitement sont également décrits. Des procédés de modulation, de normalisation ou d'amélioration des marqueurs énergétiques, de même que des composés utiles pour de tels procédés, sont également décrits.
Hinman Andrew W.
Wesson Kieron E.
Borden Ladner Gervais Llp
Edison Pharmaceuticals Inc.
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