Heteroaryl-3-oxo-propanenitrile derivatives useful in the...

Details Heteroaryl-3-oxo-propanenitrile derivatives useful in the... Heteroaryl-3-oxo-propanenitrile derivatives useful in the...

A - Human Necessities

61

K

167/211, 167/238

A61K 31/44 (2006.01) A61K 31/415 (2006.01) A61K 31/675 (2006.01)

Patent

CA 2030530

- 48 - ABSTRACT HETEROARYL-3-OXO-PROPANENITRILE DERIVATIVES USEFUL IN THE TREATMENT OF RHEUMATOID ARTHRITIS AND OTHER AUTOIMMUNE DISEASES Heteroaryl-3-oxo-propanenitrile derivativeS of formula (I) Image (I) wherein X represents an oxygen atom or a -CH(R4)-, -O-CH(R4)-, -S(O)n-CH(R4)-, -CH(R4)-O-, -CH(R4)-S(O)n- or -CH(R4)-CH2- group wherein n is 0, 1 or 2; R1 represents C1-C6 alkyl, pyridyl or unsubstituted or substituted phenyl; R2, R3, and R4 are as herein defined; and Q is hydrogen, carboxy, C2-C7-alkoxycarbonyl or a -CON(Ra)Rb group, Ra and Rb being as defined herein; and their pharmaceutically acceptable salts are useful in the preparation of pharmaceutical compositions active in the treatment of autoimmune diseases.

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