Heteroaryl-3-oxo-propanenitrile derivatives useful in...

Details Heteroaryl-3-oxo-propanenitrile derivatives useful in... Heteroaryl-3-oxo-propanenitrile derivatives useful in...

A - Human Necessities

61

K

A61K 31/415 (2006.01)

Patent

CA 2036375

- 59 - ABSTRACT HETEROARYL-3-OXO-PROPANENITRILE DERIVATIVES USEFUL IN STIMULATING MYELOPOIESIS Heteroaryl-3-oxo-propanenitrile derivatives of formula (I) Image (I) wherein X represents an oxygen atom or a -CH(R4)-, -O-CH(R4)-, -S(O)n-, -S(O)n-CH(R4)-, -CH(R4)-O-, -CH(R4)-S(O)n- or -CH(R4)-CH2- group wherein n is 0, 1 or 2; R1 represents C1-C6 alkyl, pyridyl or unsubstituted or substituted phenyl; R2, R3 and R4 are as herein defined; and Q is hydrogen, carboxy, C2-C7- alkoxycarbonyl or a -CON(Ra)Rb group, Ra and Rb being as de- fined herein; and their pharmaceutically acceptable salts are useful in stimulating myelopoiesis in bone marrow suppressed mammals.

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