C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 451/00 (2006.01) C07D 471/08 (2006.01) C07D 487/04 (2006.01) C07D 487/08 (2006.01)
Patent
CA 2389553
The present invention relates to novel heteroaryl-diazabicycloalkanes which are found to be cholinergic ligands at the nicotinic Acetyl Choline Receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neurodegeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
L'invention concerne de nouveaux hétéroaryles-diazabicycloalcanes qui se sont avérés des ligands cholinergiques au niveau des récepteurs nicotiniques d'acétylcholines. Etant donné leur profil pharmacologique, ces composés peuvent être utiles pour le traitement de maladies ou de troubles divers apparentés au système cholinergique du système nerveux central (CNS), de maladies ou de troubles apparentées à la contraction des muscles lisses, de maladies ou de troubles du système endocrinien, de maladies ou de troubles neurodégénératifs, de maladies ou de troubles provoqués par l'inflammation ou la douleur, ainsi que de symptômes de sevrage déclenchés par l'arrêt de la consommation excessive de substances chimiques.
Ahring Philip K.
Jorgensen Tino Dyhring
Nielsen Elsebet Ostergaard
Nielsen Simon Feldbaek
Olsen Gunnar M.
Mccarthy Tetrault Llp
Neurosearch A/s
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